Carbon dots for highly effective photodynamic inactivation of multidrug-resistant bacteria

Prospects for Success in Inhibiting the Growth of Multidrug-resistant Bacteria with Paromomycin

Streptomyces is the most important bacterial genus known to produce secondary antibiotic compounds. Considering the speed of bacterial resistance spread, it becomes more important to study less used compounds. Aminoglycosides disrupt the function of the target microorganism by acting on the protein-synthesis process. Paromomycin is an aminoglycoside that acts on a wide range of gram-positive, g...

Chlorin e6 mediated photodynamic inactivation for multidrug resistant Pseudomonas aeruginosa keratitis in mice in vivo

Following corneal epithelium scratches, mouse corneas were infected with the multidrug resistant (MDR) P. aeruginosa strain PA54. 24 hours later, 0% (for control group), 0.01%, 0.05% or 0.1% Chlorin e6 (Ce6), a second generation photosensitizer derived from chlorophyll, was combined with red light, for photodynamic inactivation (PDI). 1 hour or 2 days later, entire mouse eyes were enucleated an...

Resistance in antimicrobial photodynamic inactivation of bacteria.

Antibiotics have increasingly lost their impact to kill bacteria efficiently during the last 10 years. The emergence and dissemination of superbugs with resistance to multiple antibiotic classes have occurred among Gram-positive and Gram-negative strains including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter...

photodynamic inactivation of drug-resistant bacteria isolated from diabetic foot ulcers

background and objectives : due to the extensive use of antibiotics, the spread of drug-resistant bacteria is one of the most worrisome threats to public health. one strategy that can be used to overcome potential shortcomings might be the inactivation of these organisms by photodynamic therapy. in this study, we have investigated whether drug-resistant wound-associated organisms (staphylococcu...

Photodynamic inactivation effect of methylene blue and toluidine blue O on ATCC Escherichia coli and clinical isolate of multidrug-resistant Escherichia coli